Werewolf Syndrome: Causes, Symptoms, Treatment

Werewolf Syndrome or Hypertrichosis | Causes, Symptoms,Treatment

Werewolf Syndrome aka hypertrichosis is a unique genetic disorder that has left doctors and researches in a puzzle over centuries because of its bizarre causes, symptoms and other facts.

Werewolf Syndrome: Growing up I always fantasized about superheroes and mutants, just like they made in movies like X-men. Wolverine is still my favorite X-Men superhero. But honestly, I am not here to yap about my choice of films or superheroes. I was pretty curious to find out whether a person could turn into a werewolf in real life and the results I found were mind-boggling! It turns out, you can become a werewolf, but without the superpowers!

What is Hypertrichosis?

Congenital Hypertrichosis Lanuginosa, also called Werewolf syndrome or Ambras syndrome is an abnormal amount of growth of hair over the body. Informally, Hypertrichosis is also called as werewolf syndrome due to the appearance similar to the mythical werewolf. Congenital Hypertrichosis Lanuginosa (CHL) is sporadic skin disease which causes an excessive amount of hairiness, and it is usually present at the birth. Congenital Hypertrichosis Lanuginosa is called by the name ‘werewolf’ informally. However, CHL has no genetic connection to the wolves. You might hear Congenital Hypertrichosis Lanuginosa by different names such as uncontrollable hair syndrome, wolfman syndrome, wolfman disease, human werewolf syndrome, and the list continues.

Let me take a wild guess, you have known about this syndrome before, not through these names but surely in movies like Van Helsing, The Twilight Saga, and The Wolfman. There are more than 35 movies that somehow portrays the werewolf, but it is not actually as Hollywood or fictions depicts it to be. This disorder is easy to diagnose, and doctors and genetic experts have proposed several theories and explanations behind the causes, symptoms, and treatment of werewolf syndrome.

But before I tell you everything, let’s find out some interesting facts about werewolf syndrome.

You might also want to read: The Worst Disease Ever: Epidermolysis Bullosa (EB)

Facts About Werewolf Syndrome

Congenital Hypertrichosis Lanuginosa is extremely rare. About 50 cases are described and only 34 patients are positively identified with werewolf syndrome since the middle age. The chances of CHL goes from 1 to billion or even 10 billion.

  • Hypertrichosis or Werewolf Syndrome is an unusual genetic disorder marked by the abnormal growth of hair on the body.
  • The hair may grow either to only one area or spread throughout the body.
  • Some inherit this disorder by birth, and it is termed as ‘congenital werewolf syndrome.
  • Congenital werewolf syndrome can be classified as hypertrichosis lanuginosa, generalized hypertrichosis, terminal hypertrichosis, localized hypertrichosis, nevoid hypertrichosis, circumscribed hypertrichosis and so on, depending upon the areas where hair grows abnormally.
  • There’s still no ultimate cure for this disorder. However, there are certain drugs which might slow the rate of hair growth.
  • It’s usually a cosmetic problem. Hence you can perform laser surgery or electrolysis to get rid of the unwanted hairs from your face and body.

Back to where I was saying, let’s dig more about Werewolf disease.

Overview of Hypertrichosis

Werewolf Syndrome Causes

There can be many different causes of this disorder like congenital hypertrichosis and acquired hypertrichosis. The overall cause of hypertrichosis is still unknown. Scientists consider hypertrichosis as a form of genetic disorder which arise due to spontaneous mutation in the DNA sequence. It is known that the mutation leading to congenital generalized hypertrichosis is located between q24-q27 regions of the X-chromosome. The condition can happen to both men and women. Though the causes aren’t well understood, some possible causes can be porphyria cutanea tarda, a condition where your skin is sensitive to light, malnutrition, and cancer. Anorexia nervosa, an eating disorder is also believed to be a possible cause.

The only explainable cause of this syndrome is a genetic mutation. The genes that control and stimulate hair growth to undergo alteration, leading hairs to grow abnormally on the body. Congenital hypertrichosis is inherited in the family whereas acquired or generalized hypertrichosis might develop later in a person’s life. Some of the possible causes for a person to suffer acquired hypertrichosis include:

  • autoimmune diseases or infections during early age
  • reaction to certain drugs like hair regenerating drugs or immunosuppressants or androgenic steroids.
  • cell mutation or cancer
  • malnutrition or poor diet
  • Anorexia and other eating disorders

Other causes of hypertrichosis might include a rare condition known as Porphyria cutanea tarda. It results in the skin to go sensitive to UV rays and trigger the abnormal growth of hair all over the exposed body. Another underlying cause might be due to certain chronic skin conditions like lichen simplex. Lichen simplex is another rare skin disorder that results in rashes and itchiness in a particular area of the skin and this might also trigger hypertrichosis. Certain androgenic drugs like hair growing minoxidil or cyclosporine can also cause werewolf syndrome.

You might also want to read: Itchy Hands: Here Are The 7 Causes Of Itchy Skin

Discovery of Werewolf Disease:

According to various source on the internet, the first recorded case of Congenital Hypertrichosis Lanuginosa was Petrus Gonsalvus of the Canary Islands. This was documented by Altrovandus in the mid-17th century and published in his text Monstrorum Historia cum Paralipomenis Historiae Omnium Animalium published in 1642.

Types of Hypertrichosis:

There are various types of hypertrichosis:

1.     Congenital hypertrichosis lanuginosa:

This type of hypertrichosis first appears as a normal lanugo, fine, soft hair, especially that covers the body and limbs of a human fetus. It appears as the fine hair found on a baby at birth, but rather than disappearing after weeks, the hair continues to grow in various places on the baby’s body. This hypertrichosis is noticeable at birth, it doesn’t affect the baby’s hands and feet. As the child gets older, the thinning of hair can happen, leaving small pieces of hypertrichosis.

2.     Generalized Hypertrichosis:

This kind of hypertrichosis causes men to have excessive facial hair and hair at the upper body. Women get less severe hair affects as compared to men. Generalized hypertrichosis does not affect the hands and feet.

3.     Congenital hypertrichosis terminalis

The baby is not born with lanugo or vellus hair but may have terminal hair at birth which keeps growing throughout the life. Vellus hair is usually soft, short and faintly pigmented. This may appear all over the body except the areas where there are no hair follicles such as the palm of hands, soles of the feet. Terminal hairs are the darkest types of hair, which is usually thick, coarse and long. You can find this hair typically on the face, armpits, and groin.

4.     Nevoid hypertrichosis

It may be present at birth or can also happen in life later. It is not related to any other disease and there is an area of excessive terminal hair growth. Terminal hair appears in a defined area and in few cases more than one patch of hair is present. Unibrow, very solid and bushy monobrow, is a typical example of nevoid hypertrichosis.

5.     Hirsutism

This hypertrichosis limits to women affecting up to 10 percent of women. The women develop coarse terminal hairs in a typical male hair-growth distribution pattern like on the chest and chin. It is often due to hormone imbalance.

6.     Acquired hypertrichosis

This develops later in life which results in the development of two types of hair: vellus hair or terminal hair. Excess hair grows in small patches or all hair-growing areas of the body. By avoiding the use of certain drugs which results in hypertrichosis, the risk of acquired hypertrichosis can be reduced

Let’s discuss the symptoms of hypertrichosis.

Werewolf Syndrome Symptoms

The one peculiar symptom of werewolf syndrome is abnormal growth of hair on your body, particularly on the face and other exposed areas, resembling like a werewolf. A person suffering from this disorder produce three types of hair.

The hypertrichosis can result in three different kinds of hair:

1.     Lanugo

Lanugo hair is thin, long very soft hair similar to the hair on the body of a newborn baby. This types of hair typically have no pigments and usually disappears and fall out within a few weeks after birth. On people with hypertrichosis, the lanugo hair doesn’t fall out and remain in the body until it’s treated.

2.     Vellus

Vellus, which is a short hair located in particular areas of your body such as the back of your ears, lips, palms, scar tissue and so on. This hair is usually soft, short and faintly pigmented and these hairs appear all over the body. Vellus hair doesn’t appear in parts where there are no hair follicles such as the mucous membranes, soles of the feet and palm of hands.

3.     Terminal

Terminal hair is the darkest of all three hair types and it is often thick, coarse and long hair. You can find this hair on the face, armpits, and groin. It usually associates with hormones.

Symptoms like missing gums or enlarged gums also characterize Werewolf syndrome. Often mistaken for Hirsutism, which is a disorder affecting women where they suffer unwanted growth of hair on their face and body in male-pattern, typically on the face, chest, and back.

Werewolf Syndrome Treatment

Hypertrichosis, unlike other diseases, is an extremely rare disorder and until now, only 50 cases of this syndrome have been recorded. Hirsutism, on the other hand, is prevalent in nearly 10% of the female population in the U.S. alone. Since werewolf syndrome is rare and unusual, there’s no cure for this disorder. The treatment only involves managing the symptoms and removing the hair from the affected areas. There are some home remedies you can do at home or clinical methods.

The only treatment for this disorder is removing the unusual hair through cosmetic surgery. And other methods that include: shaving, chemical epilation, laser surgery, waxing, bleaching and so on.

Laser surgery involves the application of special laser light over several hairs at one time. Hair loss can often be permanent with these treatments, though you may need a few sessions to complete the job.

Home Treatment

The home treatment includes some basic hair removal strategies that you can do at home. The home treatment includes some short-term methods of hair removal such as shaving, plucking, waxing, bleaching, and chemical epilation. You can shave or pluck the hair from the affected areas. You can remove the hair by waxing the hair from affected parts of the body. Bleaching of the hair changes the shades of the hair giving a lighter shade, but bleaching can damage your hair. Chemical epilation means using chemicals to weaken the hair by breaking the disulfide bonds in the hair keratin. The breaking of enough chemical bonds makes it possible to rub or scrap the hair emerging from the follicle. There are different hair removal creams for chemical epilation.

These temporary solutions can minimize the appearance of hair in the area but the hair will grow back again. Also, these methods can cause skin irritation and cause rashes. Also, these techniques are hard to apply in certain regions of the body.

Clinal Method

A clinical proposed method for treatment of hair is Electrolysis or laser treatment. Although there are multiple conflicting reports regarding the effectiveness of the treatment. Littler found that there is 40-80 percent reduction in unwanted hair after using the Q-switched laser after application of a topical carbon-based solution. This method of hair treatment has less pain during the treatment compared to home treatments. Neodymium: YAG (Nd:YAG) laser subsequent to an application of a topical carbon-based solution treats the affected areas. The electrical charges destroy the individual hair follicles. The treatment may result in permanent hair loss for some people, through patients might need multiple sessions of the treatment to achieve the desired result. This is a safe and effective method for reducing hair density. Electrolysis or laser treatment is an attractive method for children due to the low associated pain during treatment.

Prevention is better than cure. You might be wondering if prevention exists for hypertrichosis.

Can we Prevent Hypertrichosis?

Several ways are there to prevent Hypertrichosis. You can prevent acquired hypertrichosis, but not the congenital hypertrichosis. You can prevent the acquired hypertrichosis by avoiding the use of certain drugs that cause the condition. Weightlifters and bodybuilders can avoid the use of anabolic steroids to prevent acquired hypertrichosis from occurring. You can only congenital hypertrichosis but not prevent it. Avoiding such androgenic steroids, hair growth drugs, and certain immunosuppressants can reduce the risk of developing acquired hypertrichosis.

Now as you came to know that you cannot prevent congenital hypertrichosis and you can reduce the risk of acquired hypertrichosis. Is there a treatment to hypertrichosis?

Conclusion

Jumping to the conclusion, Congenital Hypertrichosis Lanuginosa is informally called as werewolf syndrome, because of the appearance similar to the mythical werewolf. Congenital Hypertrichosis Lanuginosa (CHL) is extremely rare skin disease which causes an excessive amount of hairiness and it is usually present at the birth. This disease is extremely rare. The acquired hypertrichosis can be prevented but the congenital hypertrichosis is out of control.  You might hear CHL by different names such as uncontrollable hair syndrome, wolfman syndrome, wolfman disease, human werewolf syndrome.

I would love to hear your thoughts and be glad to answer your queries. So go ahead, share the love, and let us know your thoughts.

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